1H-Pyrrolo[2,3-b]pyridine-4-carboxamide
1H-Pyrrolo[2,3-b]pyridine-4-carboxamide
CAS: 1086390-83-1
Molecular Formula: C8H7N3O
1H-Pyrrolo[2,3-b]pyridine-4-carboxamide - Names and Identifiers
| Name | 1H-Pyrrolo[2,3-b]pyridine-4-carboxamide |
| Synonyms | 1H-Pyrrolo[2,3-b]pyridine-4-carboxamide |
| CAS | 1086390-83-1 |
1H-Pyrrolo[2,3-b]pyridine-4-carboxamide - Physico-chemical Properties
| Molecular Formula | C8H7N3O |
| Molar Mass | 161.16 |
| Density | 1.416±0.06 g/cm3(Predicted) |
| pKa | 12.92±0.40(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | IRRITANT |
| MDL | MFCD11046289 |
1H-Pyrrolo[2,3-b]pyridine-4-carboxamide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
1H-Pyrrolo[2,3-b]pyridine-4-carboxamide - Introduction
1H-Pyrrolo[2,3-b]pyridine-4-carboxamide is an organic compound whose chemical formula is C10H6N2O. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White solid
-melting point: 149-150 ℃
-Solubility: Soluble in some organic solvents such as dichloromethane, chloroform and ethanol, but insoluble in water
-Stability: relatively stable at room temperature
Use:
1H-Pyrrolo[2,3-b]pyridine-4-carboxamide has certain application value in the field of medicine, such:
-Anti-tumor activity: The compound was found to have anti-tumor activity and may be used for the development of anti-tumor drugs.
-Biological activity research: It can be used as a precursor of biologically active compounds for research on the synthesis of active drugs and biological activity evaluation.
Preparation Method:
1H-Pyrrolo[2,3-b]pyridine-4-carboxamide can be synthesized by the following steps:
1. The reaction of 3-picolylamine with acetone in acetic acid gives ethyl 3-(pyridylmethyl)-2-pyruvate.
2. reaction of ethyl 3-(pyridylmethyl)-2-pyruvate with formyl chloride under the catalysis of copper carbonate to obtain 1H-Pyrrolo[2,3-b]pyridine-4-carboxamide.
Safety Information:
Specific safety information for the 1H-Pyrrolo[2,3-b]pyridine-4-carboxamide may need to be obtained from the vendor or from relevant safety databases. In general, the handling of organic compounds should pay attention to the following:
-Avoid skin and eye contact: Use protective gloves and glasses for protection.
-Avoid inhalation: Maintain good ventilation during operation.
-Storage Note: Store the compound in a dry, dark place, and away from fire and oxidizing agents.
At the same time, handling chemicals must follow appropriate laboratory safety practices and comply with local laws and regulations.
Nature:
-Appearance: White solid
-melting point: 149-150 ℃
-Solubility: Soluble in some organic solvents such as dichloromethane, chloroform and ethanol, but insoluble in water
-Stability: relatively stable at room temperature
Use:
1H-Pyrrolo[2,3-b]pyridine-4-carboxamide has certain application value in the field of medicine, such:
-Anti-tumor activity: The compound was found to have anti-tumor activity and may be used for the development of anti-tumor drugs.
-Biological activity research: It can be used as a precursor of biologically active compounds for research on the synthesis of active drugs and biological activity evaluation.
Preparation Method:
1H-Pyrrolo[2,3-b]pyridine-4-carboxamide can be synthesized by the following steps:
1. The reaction of 3-picolylamine with acetone in acetic acid gives ethyl 3-(pyridylmethyl)-2-pyruvate.
2. reaction of ethyl 3-(pyridylmethyl)-2-pyruvate with formyl chloride under the catalysis of copper carbonate to obtain 1H-Pyrrolo[2,3-b]pyridine-4-carboxamide.
Safety Information:
Specific safety information for the 1H-Pyrrolo[2,3-b]pyridine-4-carboxamide may need to be obtained from the vendor or from relevant safety databases. In general, the handling of organic compounds should pay attention to the following:
-Avoid skin and eye contact: Use protective gloves and glasses for protection.
-Avoid inhalation: Maintain good ventilation during operation.
-Storage Note: Store the compound in a dry, dark place, and away from fire and oxidizing agents.
At the same time, handling chemicals must follow appropriate laboratory safety practices and comply with local laws and regulations.
Last Update：2024-04-09 21:11:58
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